THE IDENTIFICATION OF THE METABOLISM SUBTYPES OF SKIN CUTANEOUS MELANOMA ASSOCIATED WITH THE TUMOR MICROENVIRONMENT AND THE IMMUNOTHERAPY

The Identification of the Metabolism Subtypes of Skin Cutaneous Melanoma Associated With the Tumor Microenvironment and the Immunotherapy

Skin cutaneous melanoma (SKCM) is a highly aggressive and resistant cancer with immense metabolic heterogeneity.Here, we performed a comprehensive examination of the diverse metabolic signatures of SKCM based on non-negative matrix factorization (NMF) categorization, clustering SKCM into three distinct metabolic subtypes (C1, C2, and C3).Next, we e

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Interleukin-10 induces expression of CD39 on CD8+T cells to potentiate anti-PD1 efficacy in EGFR-mutated non-small cell lung cancer

Background Anti-PD-1(L1) therapies are less efficacious in patients with EGFR-mutated non-small-cell lung cancer.However, the underlying mechanism is poorly understood.Methods The characteristics of T cells in EGFR-mutated and wild-type tumors were analyzed based on The Cancer Genome Atlas database and clinical samples.Plasma levels of 8 T-cell-rel

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Zeta division in the April war 1941

Studying the role of Zeta division in the April war is significant, first of all, because that unit was a rare one to have a task of an offensive towards Albania in order Ring to make retreat of the whole army towards Greece easier.Although military weaker and often without artillery and aviation support, infantry regiments of Zeta division succeed

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Assessing the influence of fly ash and polypropylene fiber on fresh, mechanical and durability properties of concrete

This paper focuses on the investigation of fresh, mechanical, and durability properties of concrete with the influence of fly ash and polypropylene fiber.In this study, cement was partially replaced by 15 % and 30 % fly ash content in weight, whereas polypropylene fiber was incorporated in concrete mixes at 0.06 %, 0.12 %, and 0.18 % by volume.Twel

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